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Restless legs syndrome

FRMD4A · rs12218808

Where this position leads

Condition: Restless Legs Syndrome

rs12218808 Condition: Restless Legs Syndrome Restless Legs Syndrome Condition rs12218808 rs12218808 FRMD4A

What the study found

Who was studied 116,647 European ancestry cases, 1,546,466 European ancestry controls; replicated in 29,028 cases, 398,815 controls.

The effect Each copy of the T allele shifted the measure 0.0414 lower (95% confidence interval 0.031-0.052); p = 4 × 10−15.

How common The T allele had a frequency of about 79% in the people studied.

Where it sits Chromosome 10, band 10p13 — in an intron of FRMD4A.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of Restless legs syndrome — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Restless legs syndrome.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Restless legs syndrome compared to the general population.
Source
Genome-wide meta-analyses of restless legs syndrome yield insights into genetic architecture, disease biology and risk prediction
Schormair B, Zhao C, Bell S, Didriksen M, Nawaz MS, Schandra N, Stefani A, Högl B, Dauvilliers Y, Bachmann CG, Kemlink D, Sonka K
and 55 more — show all
Paulus W, Trenkwalder C, Oertel WH, Hornyak M, Teder-Laving M, Metspalu A, Hadjigeorgiou GM, Polo O, Fietze I, Ross OA, Wszolek ZK, Ibrahim A, Bergmann M, Kittke V, Harrer P, Dowsett J, Chenini S, Ostrowski SR, Sørensen E, Erikstrup C, Pedersen OB, Topholm Bruun M, Nielsen KR, Butterworth AS, Soranzo N, Ouwehand WH, Roberts DJ, Danesh J, Burchell B, Furlotte NA, Nandakumar P, Earley CJ, Ondo WG, Xiong L, Desautels A, Perola M, Vodicka P, Dina C, Stoll M, Franke A, Lieb W, Stewart AFR, Shah SH, Gieger C, Peters A, Rye DB, Rouleau GA, Berger K, Stefansson H, Ullum H, Stefansson K, Hinds DA, Di Angelantonio E, Oexle K, Winkelmann J
23andMe Research Team · D.E.S.I.R. study group
Nature genetics · 2024 · PMID 38839884 · open access

Questions about rs12218808

What is rs12218808?

rs12218808 is a single position in the genome, in or near the FRMD4A gene. Published research associates it with restless legs syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12218808 linked to?

On MyGeneLog this position is linked to Restless Legs Syndrome. The research behind each link, and its sources, are set out on that condition page.

Does having rs12218808 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12218808 come from?

GWAS Catalog, Nature genetics 2024, PMID:38839884. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Restless legs syndrome (rs12218808). MyGeneLog™. https://www.mygenelog.com/variants/rs12218808

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