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Who was studied 98,805 European ancestry cases, 948,186 European ancestry controls, 14,588 cases, 117,082 controls; replicated in 34,835 European ancestry cases, 492,149 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.051 higher (95% confidence interval 0.037-0.065); p = 4 × 10−13.
How common The T allele had a frequency of about 13% in the people studied.
Where it sits Chromosome 6, band 6q21 — in an intron of SESN1.
What each result means
C/CNo copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 41238958 · open access
Questions about rs12206423
What is rs12206423?
rs12206423 is a single position in the genome, in or near the SESN1 gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12206423 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs12206423 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12206423 come from?
GWAS Catalog, Nature genetics 2025, PMID:41238958. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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