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Who was studied 188,039 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.03 z score higher (95% confidence interval 0.02-0.04); p = 4 × 10−10.
How common The T allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 6, band 6q21 — in an intron of SESN1.
What each result means
C/CNo copy of the version the research linked to Birth weight. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Birth weight. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Birth weight. That is the strongest link of the three results. A link in a study is not a diagnosis.
The British journal of ophthalmology · 2020 · PMID 31097437
Questions about rs12197912
What is rs12197912?
rs12197912 is a single position in the genome, in or near the SESN1 gene. Published research associates it with birth weight. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12197912 linked to?
On MyGeneLog this position is linked to Birth Weight. The research behind each link, and its sources, are set out on that condition page.
Does having rs12197912 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12197912 come from?
GWAS Catalog, The British journal of ophthalmology 2020, PMID:31097437. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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