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Hand grip strength

near ZNF322 · rs12195114

Where this position leads

Condition: Hand Grip Strength

rs12195114 Condition: Hand Grip Strength Hand Grip Strength Condition rs12195114 rs12195114 near ZNF322

What the study found

Who was studied 334,825 British ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.002 lower (95% confidence interval 0.0014-0.0026); p = 7 × 10−10.

How common The A allele had a frequency of about 75% in the people studied.

Where it sits Chromosome 6, band 6p22.2 — in an intron of LOC105374991.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hand grip strength compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hand grip strength.
G/G Published research associates this genotype with typical/baseline likelihood of Hand grip strength — no copies of the reported risk allele.
Source
Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank
Tikkanen E, Gustafsson S, Amar D, Shcherbina A, Waggott D, Ashley EA, Ingelsson E
Scientific reports · 2018 · PMID 29691431 · open access

Questions about rs12195114

What is rs12195114?

rs12195114 is a single position in the genome, in or near the near ZNF322 gene. Published research associates it with hand grip strength. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12195114 linked to?

On MyGeneLog this position is linked to Hand Grip Strength. The research behind each link, and its sources, are set out on that condition page.

Does having rs12195114 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12195114 come from?

GWAS Catalog, Sci Rep 2018, PMID:29691431. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Hand grip strength (rs12195114). MyGeneLog™. https://www.mygenelog.com/variants/rs12195114

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