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Axial length

ARHGAP18 · rs12193446

What the study found

Who was studied 12,531 European ancestry individuals; replicated in 8,216 Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.122 higher (95% confidence interval 0.08-0.164); p = 1 × 10−8.

How common The A allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 6, band 6q22.33 — in an intron of LOC102723409.

What each result means

A/A Two copies of the version the research linked to Axial length. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Axial length. That is a smaller link than two copies.
G/G No copy of the version the research linked to Axial length. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs12193446

What is rs12193446?

rs12193446 is a single position in the genome, in or near the ARHGAP18 gene. Published research associates it with axial length. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs12193446?

Subjects that appear in the title or abstract of the same papers as this rsID include short-sightedness and screens (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs12193446 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12193446 come from?

GWAS Catalog, Am J Hum Genet 2013, PMID:24144296. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Axial length (rs12193446). MyGeneLog™. https://www.mygenelog.com/variants/rs12193446

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