3 4632536223119Reads by AI crawlersClaude3ChatGPT2Google · Gemini5Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others19Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 1,359 European ancestry cases, 1,400 European ancestry controls; replicated in 5,048 European ancestry cases, 5,041 European ancestry controls.
The effect
Each copy of the T allele carried 2.64 times the odds of Psoriasis; p = 1 × 10−100.
How common The T allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 2.4 kb from WASF5P.
What each result means
C/CNo copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2009 · PMID 19169254 · open access
Questions about rs12191877
What is rs12191877?
rs12191877 is a single position in the genome, in or near the HLA-C gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12191877 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
Does having rs12191877 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12191877 come from?
GWAS Catalog, Nat Genet 2009, PMID:19169254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 4632536223119Reads by AI crawlersClaude3ChatGPT2Google · Gemini5Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others19Total46Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.