Standard

Lipoprotein glomerulopathy

APOE · rs121918397

Where this position leads

Drug: Lecanemab and other anti-amyloid antibodies

Strength of the evidence

There is no record yet to score this position by (a ClinVar disease classification or a genome-wide significant study). That is not the same as weak evidence.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10⁻⁵⁰. 2: ClinVar from one lab (1 star), or p ≤ 10⁻²⁰. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10⁻⁸). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Conflicting classifications of pathogenicity for Familial type 3 hyperlipoproteinemia, Lipoprotein glomerulopathy, Familial hypercholesterolemia; criteria provided, conflicting classifications (1 of 4 stars, 3 submitters), last evaluated 2024-06-12. ClinVar record 17865 NM_000041.4(APOE):c.488G>A (p.Arg163His)

Classification Uncertain significance for Lipoprotein glomerulopathy; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2022-05-22. ClinVar record 1687222 NM_000041.4(APOE):c.488G>T (p.Arg163Leu)

Classification Pathogenic for Lipoprotein glomerulopathy; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2000-10-06. ClinVar record 17879 NM_000041.4(APOE):c.488G>C (p.Arg163Pro)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C Two copies of the version ClinVar lists as disease-causing for Lipoprotein glomerulopathy. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV000017879, no assertion criteria provided)

C/G One copy of the version ClinVar lists as disease-causing for Lipoprotein glomerulopathy. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV000017879, no assertion criteria provided)

G/G No copy of the version ClinVar lists as disease-causing for Lipoprotein glomerulopathy. This is the usual result. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV000017879, no assertion criteria provided)

Source: ClinVar VCV000017879, no assertion criteria provided

Questions about rs121918397

What is rs121918397?

rs121918397 is a single position in the genome, in or near the APOE gene. Published research associates it with lipoprotein glomerulopathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs121918397 affect how medicines work?

APOE carries pharmacogenomic findings for Lecanemab and other anti-amyloid antibodies. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs121918397 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs121918397 come from?

ClinVar VCV000017879, no assertion criteria provided. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Lipoprotein glomerulopathy (rs121918397). MyGeneLog™. https://www.mygenelog.com/variants/rs121918397

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