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Who was studied at least 60,620 European ancestry cases, at least 970,216 European ancestry controls (MTAG boosted by 455,258 Alzheimer's disease samples).
The effect
Each copy of the C allele shifted the measure 0.00926 lower (95% confidence interval 0.0062-0.0123); p = 3 × 10−9.
Where it sits Chromosome 1, band 1q21.3 — in an intron of KCNN3.
What each result means
C/CTwo copies of the version the research linked to Atrial fibrillation (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Atrial fibrillation (MTAG). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Atrial fibrillation (MTAG). This is the starting point the study compared everyone against.
Nature communications · 2024 · PMID 39537608 · open access
Questions about rs1218550
What is rs1218550?
rs1218550 is a single position in the genome, in or near the KCNN3 gene. Published research associates it with atrial fibrillation (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1218550 linked to?
On MyGeneLog this position is linked to Atrial Fibrillation. The research behind each link, and its sources, are set out on that condition page.
Does having rs1218550 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1218550 come from?
GWAS Catalog, Nature communications 2024, PMID:39537608. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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