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Who was studied 11,489 European ancestry cases with celiac disease, 15,523 European ancestry cases with rheumatoid arthritis, 3,477 European ancestry cases with systemic sclerosis, 6,670 European ancestry cases with type 1 diabetes, 22,308 European ancestry controls.
The effect
The reported allele is C; the catalogue records no effect size
; p = 5 × 10−11.
Where it sits Chromosome 1, band 1p13.2 — in an intron of PTPN22.
What each result means
C/CTwo copies of the version the research linked to Autoimmune traits (pleiotropy). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Autoimmune traits (pleiotropy). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Autoimmune traits (pleiotropy). This is the starting point the study compared everyone against.
Genome medicine · 2018 · PMID 30572963 · open access
Questions about rs1217403
What is rs1217403?
rs1217403 is a single position in the genome, in or near the PTPN22 gene. Published research associates it with autoimmune traits (pleiotropy). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1217403 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs1217403 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1217403 come from?
GWAS Catalog, Genome medicine 2018, PMID:30572963. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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