Triglycerides to Total Lipids in Large LDL percentage
near GSTT4 · rs12158430
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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.
The effect
Each copy of the T allele shifted the measure 0.02 % higher (95% confidence interval 0.02-0.02); p = 4 × 10−11.
Where it sits Chromosome 22, band 22q11.23 — between genes, 3.3 kb from GSTT4.
What each result means
G/GPublished research associates this genotype with typical/baseline likelihood of Triglycerides to Total Lipids in Large LDL percentage — no copies of the reported risk allele.
G/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Triglycerides to Total Lipids in Large LDL percentage.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Triglycerides to Total Lipids in Large LDL percentage compared to the general population.
Nature genetics · 2025 · PMID 41044249 · open access
Questions about rs12158430
What is rs12158430?
rs12158430 is a single position in the genome, in or near the near GSTT4 gene. Published research associates it with triglycerides to total lipids in large ldl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12158430 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12158430 come from?
GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Triglycerides to Total Lipids in Large LDL percentage (rs12158430). MyGeneLog™. https://www.mygenelog.com/variants/rs12158430