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Body mass index (SNP x SNP interaction)

FTO · rs12149832

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 26,620 Japanese ancestry individuals; replicated in 35,625 East Asian ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.073 higher (95% confidence interval 0.057-0.089); p = 5 × 10⁻²².

How common The A allele had a frequency of about 20% in the people studied.

Where it sits Chromosome 16, band 16q12.2 — in an intron of FTO.

What each result means

A/A Two copies of the version the research linked to Body mass index (SNP x SNP interaction). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Body mass index (SNP x SNP interaction). That is a smaller link than two copies.

G/G No copy of the version the research linked to Body mass index (SNP x SNP interaction). This is the starting point the study compared everyone against.

Source

Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations

Okada Y, Kubo M, Ohmiya H, Takahashi A, Kumasaka N, Hosono N, Maeda S, Wen W, Dorajoo R, Go MJ, Zheng W, Zheng W

and 8 more — show all

Kato N, Wu JY, Lu Q, Tsunoda T, Yamamoto K, Nakamura Y, Kamatani N, Tanaka T

GIANT consortium

Nature genetics · 2012 · PMID 22344221

What people read about alongside this

Blood sugar and insulin1 Kidneys1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs12149832

What is rs12149832?

rs12149832 is a single position in the genome, in or near the FTO gene. Published research associates it with body mass index (snp x snp interaction). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs12149832?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), kidneys (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs12149832 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12149832 come from?

GWAS Catalog, Nat Genet 2012, PMID:22344221. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body mass index (SNP x SNP interaction) (rs12149832). MyGeneLog™. https://www.mygenelog.com/variants/rs12149832

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