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Lung function (FEV1/FVC)

EMP2 · rs12149828

Where this position leads

Condition: Pulmonary Function (Lung Capacity)

What the study found

Who was studied 38,199 European ancestry adults; replicated in 54,550 European ancestry adults, 5,062 children.

The effect Each copy of the G allele shifted the measure 0.04 higher (95% confidence interval 0.026-0.054); p = 8 × 10⁻¹⁰.

Where it sits Chromosome 16, band 16p13.13 — between genes, 15 kb from TEKT5.

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Lung function (FEV1/FVC) — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lung function (FEV1/FVC).

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lung function (FEV1/FVC) compared to the general population.

Source

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Soler Artigas M, Wain LV, Miller S, Kheirallah AK, Huffman JE, Ntalla I, Shrine N, Obeidat M, Trochet H, McArdle WL, Alves AC, Hui J

and 78 more — show all

Zhao JH, Joshi PK, Teumer A, Albrecht E, Imboden M, Rawal R, Lopez LM, Marten J, Enroth S, Surakka I, Polasek O, Lyytikäinen LP, Granell R, Hysi PG, Flexeder C, Mahajan A, Beilby J, Bossé Y, Brandsma CA, Campbell H, Gieger C, Gläser S, González JR, Grallert H, Hammond CJ, Harris SE, Hartikainen AL, Heliövaara M, Henderson J, Hocking L, Horikoshi M, Hutri-Kähönen N, Ingelsson E, Johansson Å, Kemp JP, Kolcic I, Kumar A, Lind L, Melén E, Musk AW, Navarro P, Nickle DC, Padmanabhan S, Raitakari OT, Ried JS, Ripatti S, Schulz H, Scott RA, Sin DD, Starr JM, Viñuela A, Völzke H, Wild SH, Wright AF, Zemunik T, Jarvis DL, Spector TD, Evans DM, Lehtimäki T, Vitart V, Kähönen M, Gyllensten U, Rudan I, Deary IJ, Karrasch S, Probst-Hensch NM, Heinrich J, Stubbe B, Wilson JF, Wareham NJ, James AL, Morris AP, Jarvelin MR, Hayward C, Sayers I, Strachan DP, Hall IP, Tobin MD

UK BiLEVE

Nature communications · 2015 · PMID 26635082 · open access

Questions about rs12149828

What is rs12149828?

rs12149828 is a single position in the genome, in or near the EMP2 gene. Published research associates it with lung function (fev1/fvc). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12149828 linked to?

On MyGeneLog this position is linked to Pulmonary Function (Lung Capacity). The research behind each link, and its sources, are set out on that condition page.

Does having rs12149828 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12149828 come from?

GWAS Catalog, Nat Commun 2015, PMID:26635082. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung function (FEV1/FVC) (rs12149828). MyGeneLog™. https://www.mygenelog.com/variants/rs12149828

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