Sensitive

Systemic lupus erythematosus

TRAF3 · rs12148050

Where this position leads

What each result means

A/A Published research associates this genotype with typical/baseline likelihood of Systemic lupus erythematosus — no copies of the reported risk allele.

A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Systemic lupus erythematosus.

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Systemic lupus erythematosus compared to the general population.

Source

Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups

Wang YF, Zhang Y, Lin Z, Zhang H, Wang TY, Cao Y, Morris DL, Sheng Y, Yin X, Zhong SL, Gu X, Lei Y

and 23 more — show all

He J, Wu Q, Shen JJ, Yang J, Lam TH, Lin JH, Mai ZM, Guo M, Tang Y, Chen Y, Song Q, Ban B, Mok CC, Cui Y, Lu L, Shen N, Sham PC, Lau CS, Smith DK, Vyse TJ, Zhang X, Lau YL, Yang W

Nature communications · 2021 · PMID 33536424 · open access

Questions about rs12148050

What is rs12148050?

rs12148050 is a single position in the genome, in or near the TRAF3 gene. Published research associates it with systemic lupus erythematosus. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12148050 linked to?

On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.

Does having rs12148050 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12148050 come from?

GWAS Catalog, Nat Commun 2021, PMID:33536424. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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