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Height

PHGDH · rs12144094

Where this position leads

Condition: Height

rs12144094 Condition: Height Height Condition rs12144094 rs12144094 PHGDH

What the study found

Who was studied 253,288 European ancestry individuals; replicated in 80,067 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.025 higher (95% confidence interval 0.017-0.033); p = 2 × 10−9.

How common The C allele had a frequency of about 84% in the people studied.

Where it sits Chromosome 1, band 1p12 — in an intron of PHGDH.

What each result means

C/C Two copies of the version the research linked to Height. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/G One copy of the version the research linked to Height. That is a smaller link than two copies.
G/G No copy of the version the research linked to Height. This is the starting point the study compared everyone against.
Source

Questions about rs12144094

What is rs12144094?

rs12144094 is a single position in the genome, in or near the PHGDH gene. Published research associates it with height. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12144094 linked to?

On MyGeneLog this position is linked to Height. The research behind each link, and its sources, are set out on that condition page.

Does having rs12144094 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12144094 come from?

GWAS Catalog, Nature genetics 2014, PMID:25282103. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Height (rs12144094). MyGeneLog™. https://www.mygenelog.com/variants/rs12144094

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