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Its strongest genetic-study result is p = 10−11, with 2 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 430,445 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0155 lower (95% confidence interval 0.011-0.02); p = 1 × 10−11.
How common The G allele had a frequency of about 43% in the people studied.
Where it sits Chromosome 1, band 1p31.1 — in an intron of NEGR1.
What each result means
A/ANo copy of the version the research linked to Highest math class taken. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Highest math class taken. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Highest math class taken. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs12136092 is a single position in the genome, in or near the NEGR1 gene. Published research associates it with highest math class taken. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12136092 linked to?
On MyGeneLog this position is linked to Educational Attainment. The research behind each link, and its sources, are set out on that condition page.
Does having rs12136092 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12136092 come from?
GWAS Catalog, Nature genetics 2018, PMID:30038396. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Highest math class taken (rs12136092). MyGeneLog™. https://www.mygenelog.com/variants/rs12136092