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Insomnia

NEGR1 · rs12134600

Where this position leads

Condition: Insomnia

rs12134600 Condition: Insomnia Insomnia Condition rs12134600 rs12134600 NEGR1

What the study found

Who was studied 593,724 European ancestry cases, 1,771,286 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.013 higher (95% confidence interval 0.011-0.015); p = 1 × 10−21.

Where it sits Chromosome 1, band 1p31.1 — in an intron of NEGR1.

What each result means

A/A Two copies of the version the research linked to Insomnia. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Insomnia. That is a smaller link than two copies.
C/C No copy of the version the research linked to Insomnia. This is the starting point the study compared everyone against.
Source

Questions about rs12134600

What is rs12134600?

rs12134600 is a single position in the genome, in or near the NEGR1 gene. Published research associates it with insomnia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12134600 linked to?

On MyGeneLog this position is linked to Insomnia. The research behind each link, and its sources, are set out on that condition page.

Does having rs12134600 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12134600 come from?

GWAS Catalog, Nature genetics 2022, PMID:35835914. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Insomnia (rs12134600). MyGeneLog™. https://www.mygenelog.com/variants/rs12134600

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