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Migraine

TSPAN2 · rs12134493

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Migraine compared to the general population. (GWAS Catalog, Nat Genet 2013, PMID:23793025)

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Migraine. (GWAS Catalog, Nat Genet 2013, PMID:23793025)

C/C Published research associates this genotype with typical/baseline likelihood of Migraine — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2013, PMID:23793025)

Source

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G, Kallela M, Malik R, de Vries B, Terwindt G, Medland SE, Todt U

and 85 more — show all

McArdle WL, Quaye L, Koiranen M, Ikram MA, Lehtimäki T, Stam AH, Ligthart L, Wedenoja J, Dunham I, Neale BM, Palta P, Hamalainen E, Schürks M, Rose LM, Buring JE, Ridker PM, Steinberg S, Stefansson H, Jakobsson F, Lawlor DA, Evans DM, Ring SM, Färkkilä M, Artto V, Kaunisto MA, Freilinger T, Schoenen J, Frants RR, Pelzer N, Weller CM, Zielman R, Heath AC, Madden PAF, Montgomery GW, Martin NG, Borck G, Göbel H, Heinze A, Heinze-Kuhn K, Williams FMK, Hartikainen AL, Pouta A, van den Ende J, Uitterlinden AG, Hofman A, Amin N, Hottenga JJ, Vink JM, Heikkilä K, Alexander M, Muller-Myhsok B, Schreiber S, Meitinger T, Wichmann HE, Aromaa A, Eriksson JG, Traynor B, Trabzuni D, Rossin E, Lage K, Jacobs SBR, Jacobs SBR, Gibbs JR, Birney E, Kaprio J, Penninx BW, Boomsma DI, van Duijn C, van Duijn C, Raitakari O, Jarvelin MR, Zwart JA, Cherkas L, Strachan DP, Kubisch C, Ferrari MD, van den Maagdenberg AMJM, Dichgans M, Wessman M, Smith GD, Stefansson K, Daly MJ, Nyholt DR, Chasman D, Palotie A

North American Brain Expression Consortium · UK Brain Expression Consortium

Nature genetics · 2013 · PMID 23793025 · open access

Questions about rs12134493

What is rs12134493?

rs12134493 is a single position in the genome, in or near the TSPAN2 gene. Published research associates it with migraine. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12134493 linked to?

On MyGeneLog this position is linked to Migraine. The research behind each link, and its sources, are set out on that condition page.

Does having rs12134493 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12134493 come from?

GWAS Catalog, Nat Genet 2013, PMID:23793025. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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