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Umbilical hernia

near ZC3H11B · rs12133396

Where this position leads

Condition: Umbilical Hernia

rs12133396 Condition: Umbilical Hernia Umbilical Hernia Condition rs12133396 rs12133396 near ZC3H11B

What the study found

Who was studied 3,211 European ancestry cases, 272,335 European ancestry controls; replicated in 1,078 European ancestry cases, 90,770 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 4 × 10−20.

How common The A allele had a frequency of about 24% in the people studied.

Where it sits Chromosome 1, band 1q41 — between genes, 6.6 kb from ZC3H11B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Umbilical hernia compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Umbilical hernia.
G/G Published research associates this genotype with typical/baseline likelihood of Umbilical hernia — no copies of the reported risk allele.
Source
Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank
Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J
Hernia : the journal of hernias and abdominal wall surgery · 2022 · PMID 34382107

Questions about rs12133396

What is rs12133396?

rs12133396 is a single position in the genome, in or near the near ZC3H11B gene. Published research associates it with umbilical hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12133396 linked to?

On MyGeneLog this position is linked to Umbilical Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs12133396 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12133396 come from?

GWAS Catalog, Hernia : the journal of hernias and abdominal wall surgery 2022, PMID:34382107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Umbilical hernia (rs12133396). MyGeneLog™. https://www.mygenelog.com/variants/rs12133396

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