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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 1,067,913 European ancestry individuals; replicated in 228,033 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0057 lower (95% confidence interval 0.0038-0.0076); p = 2 × 10−9.
How common The T allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 1, band 1p36.12 — between genes, 9.5 kb from ECE1.
What each result means
G/GNo copy of the version the research linked to Depressive symptoms. This is the starting point the study compared everyone against.
G/TOne copy of the version the research linked to Depressive symptoms. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Depressive symptoms. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs12131134 is a single position in the genome, in or near the near ECE1 gene. Published research associates it with depressive symptoms. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12131134 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12131134 come from?
GWAS Catalog, Nature genetics 2019, PMID:30643256. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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