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Who was studied 2,637 European ancestry cases, 364 non-array typed, familial imputed Icelandic ancestry cases, 134,811 European ancestry controls, 152,739 non-array typed, familial imputed Icelandic ancestry controls..
The effect
The reported allele is A; the catalogue records no effect size
; p = 4 × 10−11.
How common The A allele had a frequency of about 80% in the people studied.
Where it sits Chromosome 1, band 1q42.2 — in an intron of PCNX2.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Thyroid cancer compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Thyroid cancer.
G/GPublished research associates this genotype with typical/baseline likelihood of Thyroid cancer — no copies of the reported risk allele.
Nature communications · 2017 · PMID 28195142 · open access
Questions about rs12129938
What is rs12129938?
rs12129938 is a single position in the genome, in or near the PCNXL2 gene. Published research associates it with thyroid cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12129938 linked to?
On MyGeneLog this position is linked to Thyroid Cancer. The research behind each link, and its sources, are set out on that condition page.
Does having rs12129938 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12129938 come from?
GWAS Catalog, Nature communications 2017, PMID:28195142. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Thyroid cancer (rs12129938). MyGeneLog™. https://www.mygenelog.com/variants/rs12129938