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Body shape phenotype PC2

ZNF697 · rs12129705

Where this position leads

Condition: Osteoarthritis

rs12129705 Condition: Osteoarthritis Osteoarthritis Condition rs12129705 rs12129705 ZNF697

What the study found

Who was studied 460,198 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0348 higher (95% confidence interval 0.028-0.041); p = 4 × 10−26.

How common The A allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 1, band 1p12 — in the 5′ untranslated region of PHGDH.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Body shape phenotype PC2 compared to the general population.
A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Body shape phenotype PC2.
T/T Published research associates this genotype with typical/baseline likelihood of Body shape phenotype PC2 — no copies of the reported risk allele.
Source
Tissue-specific genetic variation suggests distinct molecular pathways between body shape phenotypes and colorectal cancer
Peruchet-Noray L, Sedlmeier AM, Dimou N, Baurecht H, Fervers B, Fontvieille E, Konzok J, Tsilidis KK, Christakoudi S, Jansana A, Cordova R, Bohmann P
and 18 more — show all
Stein MJ, Weber A, Bézieau S, Brenner H, Chan AT, Cheng I, Figueiredo JC, Garcia-Etxebarria K, Moreno V, Newton CC, Schmit SL, Song M, Ulrich CM, Ferrari P, Viallon V, Carreras-Torres R, Gunter MJ, Freisling H
Science advances · 2024 · PMID 38640244 · open access

Questions about rs12129705

What is rs12129705?

rs12129705 is a single position in the genome, in or near the ZNF697 gene. Published research associates it with body shape phenotype pc2. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12129705 linked to?

On MyGeneLog this position is linked to Osteoarthritis. The research behind each link, and its sources, are set out on that condition page.

Does having rs12129705 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12129705 come from?

GWAS Catalog, Science advances 2024, PMID:38640244. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Body shape phenotype PC2 (rs12129705). MyGeneLog™. https://www.mygenelog.com/variants/rs12129705

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