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White blood cell count

SNX27 · rs12122920

Where this position leads

Condition: Blood Cell Counts

rs12122920 Condition: Blood Cell Counts Blood Cell Counts Condition rs12122920 rs12122920 SNX27

What the study found

Who was studied 16,201 African American or Afro-Caribbean individuals.

The effect Each copy of the A allele shifted the measure 0.3 lower (95% confidence interval 0.27-0.33); p = 4 × 10−73.

How common The A allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 1, band 1q21.3 — in an intron of SNX27.

What each result means

A/A Two copies of the version the research linked to White blood cell count. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to White blood cell count. That is a smaller link than two copies.
G/G No copy of the version the research linked to White blood cell count. This is the starting point the study compared everyone against.
Source

Questions about rs12122920

What is rs12122920?

rs12122920 is a single position in the genome, in or near the SNX27 gene. Published research associates it with white blood cell count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12122920 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs12122920 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12122920 come from?

GWAS Catalog, BMC genomics 2021, PMID:34107879. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

White blood cell count (rs12122920). MyGeneLog™. https://www.mygenelog.com/variants/rs12122920

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