TSPAN2 · rs12122341
Where this position leads
Condition: Ischaemic Stroke
What the study found
Who was studied up to 2,349 European ancestry cases, up to 220 African ancestry cases, up to 146 Hispanic cases, 26,690 European ancestry controls, 3,354 African ancestry controls, 2,429 Hispanic controls; replicated in 33 African ancestry cases, 34 East Asian ancestry cases, 1,787 European ancestry cases, 40 Hispanic ancestry cases, 355 South Asian ancestry cases, 239 African ancestry controls, 329 East Asian ancestry controls, 176,782 European ancestry controls, 686 Hispanic controls, 5,193 South Asian ancestry controls.
The effect Each copy of the G allele carried 1.19 times the odds of Ischemic stroke (large artery atherosclerosis) (95% confidence interval 1.12-1.26); p = 1 × 10−9.
How common The G allele had a frequency of about 26% in the people studied.
Where it sits Chromosome 1, band 1p13.2 — in an intron of LINC01765.
rs12122341 is a single position in the genome, in or near the TSPAN2 gene. Published research associates it with ischemic stroke (large artery atherosclerosis). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Ischaemic Stroke. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Lancet Neurol 2015, PMID:26708676. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Ischemic stroke (large artery atherosclerosis) (rs12122341). MyGeneLog™. https://www.mygenelog.com/variants/rs12122341