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Psoriasis

FASLG · rs12118303

Where this position leads

Condition: Psoriasis

rs12118303 Condition: Psoriasis Psoriasis Condition rs12118303 rs12118303 FASLG

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Psoriasis compared to the general population. (GWAS Catalog, Nat Commun 2017, PMID:28537254)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Psoriasis. (GWAS Catalog, Nat Commun 2017, PMID:28537254)
T/T Published research associates this genotype with typical/baseline likelihood of Psoriasis — no copies of the reported risk allele. (GWAS Catalog, Nat Commun 2017, PMID:28537254)
Source
Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
Tsoi LC, Stuart PE, Tian C, Gudjonsson JE, Das S, Zawistowski M, Ellinghaus E, Barker JN, Chandran V, Dand N, Duffin KC, Enerbäck C
and 26 more — show all
Esko T, Franke A, Gladman DD, Hoffmann P, Kingo K, Kõks S, Krueger GG, Lim HW, Metspalu A, Mrowietz U, Mucha S, Rahman P, Reis A, Reis A, Tejasvi T, Trembath R, Voorhees JJ, Weidinger S, Weichenthal M, Wen X, Eriksson N, Kang HM, Hinds DA, Nair RP, Abecasis GR, Elder JT
Nature communications · 2017 · PMID 28537254 · open access

Questions about rs12118303

What is rs12118303?

rs12118303 is a single position in the genome, in or near the FASLG gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12118303 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does having rs12118303 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12118303 come from?

GWAS Catalog, Nat Commun 2017, PMID:28537254. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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