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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 69,269 Chinese ancestry females; replicated in up to 20,026 East Asian ancestry females.
The effect
Each copy of the A allele shifted the measure 0.07 lower (95% confidence interval 0.056-0.084); p = 7 × 10−22.
Where it sits Chromosome 1, band 1q22 — in an intron of SMG5.
What each result means
A/ATwo copies of the version the research linked to Glycated hemoglobin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Glycated hemoglobin levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Glycated hemoglobin levels. This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40325049 · open access
Questions about rs12118238
What is rs12118238?
rs12118238 is a single position in the genome, in or near the SMG5 gene. Published research associates it with glycated hemoglobin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12118238 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12118238 come from?
GWAS Catalog, Nature communications 2025, PMID:40325049. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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