Standard
P wave terminal force
KCND3 · rs12090194
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 33,955 European ancestry individuals, 6,778 African individuals.
The effect
Each copy of the T allele shifted the measure 119 ms x uV higher (95% confidence interval 93.52-144.48); p = 6 × 10−19.
How common The T allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 1, band 1p13.2 — in an intron of KCND3.
What each result means
C/C
Published research associates this genotype with typical/baseline likelihood of P wave terminal force — no copies of the reported risk allele.
C/T
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with P wave terminal force.
T/T
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of P wave terminal force compared to the general population.
Source
Fifteen Genetic Loci Associated With the Electrocardiographic P Wave
Christophersen IE,
Magnani JW,
Yin X,
Barnard J,
Weng LC,
Arking DE,
Niemeijer MN,
Lubitz SA,
Avery CL,
Duan Q,
Felix SB,
Bis JC
and 40 more — show all
Kerr KF,
Isaacs A,
Müller-Nurasyid M,
Müller C,
North KE,
Reiner AP,
Tinker LF,
Kors JA,
Teumer A,
Petersmann A,
Sinner MF,
Buzkova P,
Smith JD,
Van Wagoner DR,
Völker U,
Waldenberger M,
Peters A,
Meitinger T,
Limacher MC,
Wilhelmsen KC,
Psaty BM,
Hofman A,
Uitterlinden A,
Krijthe BP,
Zhang ZM,
Schnabel RB,
Kääb S,
van Duijn C,
Rotter JI,
Sotoodehnia N,
Dörr M,
Li Y,
Chung MK,
Soliman EZ,
Alonso A,
Whitsel EA,
Stricker BH,
Benjamin EJ,
Heckbert SR,
Ellinor PT
Circulation. Cardiovascular genetics · 2017 · PMID 28794112
Questions about rs12090194
What is rs12090194?
rs12090194 is a single position in the genome, in or near the KCND3 gene. Published research associates it with p wave terminal force. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12090194 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12090194 come from?
GWAS Catalog, Circ Cardiovasc Genet 2017, PMID:28794112. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants