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Who was studied 61,714 European ancestry cases, 1,178 Pakistani ancestry cases, 593,952 European ancestry controls, 2,472 Pakistani ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.0884 lower (95% confidence interval 0.063-0.114); p = 1 × 10−11.
How common The G allele had a frequency of about 9% in the people studied.
Where it sits Chromosome 1, band 1p32.3 — between genes, 18.6 kb from MIR4421.
What each result means
A/ANo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2018 · PMID 30054458 · open access
Questions about rs12088739
What is rs12088739?
rs12088739 is a single position in the genome, in or near the MIR4421 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12088739 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs12088739 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12088739 come from?
GWAS Catalog, Nat Commun 2018, PMID:30054458. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs12088739). MyGeneLog™. https://www.mygenelog.com/variants/rs12088739