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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 277 European and unknown ancestry cases, 4,836 European and unknown ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 2 × 10−8.
Where it sits Chromosome 1, band 1p31.3 — in an intron of UBE2U.
What each result means
A/ATwo copies of the version the research linked to Severe bacterial meningitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Severe bacterial meningitis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Severe bacterial meningitis. This is the starting point the study compared everyone against.
Nature communications · 2019 · PMID 31092817 · open access
Questions about rs12081070
What is rs12081070?
rs12081070 is a single position in the genome, in or near the UBE2U gene. Published research associates it with severe bacterial meningitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12081070 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12081070 come from?
GWAS Catalog, Nature communications 2019, PMID:31092817. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Severe bacterial meningitis (rs12081070). MyGeneLog™. https://www.mygenelog.com/variants/rs12081070