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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 46,685 European ancestry individuals; replicated in 4,765 non-European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 3.27 lower (95% confidence interval 2.31-4.23); p = 2 × 10−11.
How common The T allele had a frequency of about 36% in the people studied.
Where it sits Chromosome 1, band 1p36.13 — in an intron of SDHB.
What each result means
C/CNo copy of the version the research linked to Corpus callosum total area. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Corpus callosum total area. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Corpus callosum total area. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2025 · PMID 41188267 · open access
Questions about rs12073028
What is rs12073028?
rs12073028 is a single position in the genome, in or near the SDHB gene. Published research associates it with corpus callosum total area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs12073028 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12073028 come from?
GWAS Catalog, Nature communications 2025, PMID:41188267. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Corpus callosum total area (rs12073028). MyGeneLog™. https://www.mygenelog.com/variants/rs12073028