Alzheimer's disease or gastroesophageal reflux disease and/or peptic ulcer disease
PDE4B · rs12058296
0 162212Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others12Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 71,880 European ancestry Alzheimer's disease or AD-by-proxy cases, 90,175 European ancestry peptic ulcer disease and/or GERD and/or medications for their treatment cases, up to 749,530 European ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 5 × 10−9.
Where it sits Chromosome 1, band 1p31.3 — in an intron of PDE4B.
What each result means
A/ATwo copies of the version the research linked to Alzheimer's disease or gastroesophageal reflux disease and/or peptic ulcer disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Alzheimer's disease or gastroesophageal reflux disease and/or peptic ulcer disease. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Alzheimer's disease or gastroesophageal reflux disease and/or peptic ulcer disease. This is the starting point the study compared everyone against.
Communications biology · 2022 · PMID 35851147 · open access
Questions about rs12058296
What is rs12058296?
rs12058296 is a single position in the genome, in or near the PDE4B gene. Published research associates it with alzheimer's disease or gastroesophageal reflux disease and/or peptic ulcer disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12058296 linked to?
On MyGeneLog this position is linked to Alzheimer's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs12058296 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12058296 come from?
GWAS Catalog, Communications biology 2022, PMID:35851147. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 162212Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others12Total16Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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