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Resistant hypertension

CASZ1 · rs12046278

Where this position leads

Condition: Resistant Hypertension

rs12046278 Condition: Resistant Hypertension Resistant Hypertension Condition rs12046278 rs12046278 CASZ1

What the study found

Who was studied 931 European ancestry cases, 14,210 European ancestry controls.

The effect Each copy of the C allele carried 1.41 times the odds of Resistant hypertension (95% confidence interval 1.25-1.59); p = 1 × 10−8.

How common The C allele had a frequency of about 63% in the people studied.

Where it sits Chromosome 1, band 1p36.22 — in an intron of CASZ1.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Resistant hypertension compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Resistant hypertension.
T/T Published research associates this genotype with typical/baseline likelihood of Resistant hypertension — no copies of the reported risk allele.
Source
Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group
Irvin MR, Sitlani CM, Floyd JS, Psaty BM, Bis JC, Wiggins KL, Whitsel EA, Sturmer T, Stewart J, Raffield L, Sun F, Liu CT
and 32 more — show all
Xu H, Cupples AL, Tanner RM, Rossing P, Smith A, Zilhão NR, Launer LJ, Noordam R, Rotter JI, Yao J, Li X, Guo X, Limdi N, Sundaresan A, Lange L, Correa A, Stott DJ, Ford I, Jukema JW, Gudnason V, Mook-Kanamori DO, Trompet S, Palmas W, Warren HR, Hellwege JN, Giri A, O'donnell C, Hung AM, Edwards TL, Ahluwalia TS, Arnett DK, Avery CL
American journal of hypertension · 2019 · PMID 31545351

Questions about rs12046278

What is rs12046278?

rs12046278 is a single position in the genome, in or near the CASZ1 gene. Published research associates it with resistant hypertension. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12046278 linked to?

On MyGeneLog this position is linked to Resistant Hypertension. The research behind each link, and its sources, are set out on that condition page.

Does having rs12046278 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12046278 come from?

GWAS Catalog, Am J Hypertens 2019, PMID:31545351. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Resistant hypertension (rs12046278). MyGeneLog™. https://www.mygenelog.com/variants/rs12046278

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