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Who was studied 12,258 admixed American cases, 106,876 admixed American controls.
The effect
Each copy of the G allele shifted the measure 0.104 higher (95% confidence interval 0.074-0.134); p = 6 × 10−12.
How common The G allele had a frequency of about 33% in the people studied.
Where it sits Chromosome 1, band 1p36.13 — in an intron of CAPZB.
What each result means
A/ANo copy of the version the research linked to Hypothyroidism. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Hypothyroidism. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Hypothyroidism. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2026 · PMID 41644669 · open access
Questions about rs12042240
What is rs12042240?
rs12042240 is a single position in the genome, in or near the CAPZB gene. Published research associates it with hypothyroidism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12042240 linked to?
On MyGeneLog this position is linked to Hypothyroidism. The research behind each link, and its sources, are set out on that condition page.
Does having rs12042240 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12042240 come from?
GWAS Catalog, Nature genetics 2026, PMID:41644669. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 422Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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