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Umbilical hernia

near LYPLAL1-AS1 · rs12040264

Where this position leads

What the study found

Who was studied 3,211 European ancestry cases, 272,335 European ancestry controls; replicated in 1,078 European ancestry cases, 90,770 European ancestry controls.

The effect The reported allele is G; the catalogue records no effect size ; p = 2 × 10⁻¹⁷.

How common The G allele had a frequency of about 40% in the people studied.

Where it sits Chromosome 1, band 1q41 — between genes, 6.8 kb from LYPLAL1-AS1.

What each result means

G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Umbilical hernia compared to the general population.

G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Umbilical hernia.

T/T Published research associates this genotype with typical/baseline likelihood of Umbilical hernia — no copies of the reported risk allele.

Source

Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank

Wei J, Attaar M, Shi Z, Na R, Resurreccion WK, Haggerty SP, Zheng SL, Helfand BT, Ujiki MB, Xu J

Hernia : the journal of hernias and abdominal wall surgery · 2022 · PMID 34382107

Questions about rs12040264

What is rs12040264?

rs12040264 is a single position in the genome, in or near the near LYPLAL1-AS1 gene. Published research associates it with umbilical hernia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12040264 linked to?

On MyGeneLog this position is linked to Inguinal Hernia. The research behind each link, and its sources, are set out on that condition page.

Does having rs12040264 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12040264 come from?

GWAS Catalog, Hernia : the journal of hernias and abdominal wall surgery 2022, PMID:34382107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Umbilical hernia (rs12040264). MyGeneLog™. https://www.mygenelog.com/variants/rs12040264

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