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Morning person

AK5 · rs12030598

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 252,287 European ancestry cases, 150,908 European ancestry controls; replicated in 120,478 European ancestry cases, 127,622 European ancestry controls.

The effect The reported allele is A; the catalogue records no effect size ; p = 4 × 10−40.

How common The A allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 1, band 1p31.1 — in an intron of AK5.

What each result means

A/A Two copies of the version the research linked to Morning person. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Morning person. That is a smaller link than two copies.
G/G No copy of the version the research linked to Morning person. This is the starting point the study compared everyone against.
Source
Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
Jones SE, Lane JM, Wood AR, van Hees VT, Tyrrell J, Beaumont RN, Jeffries AR, Dashti HS, Hillsdon M, Ruth KS, Tuke MA, Yaghootkar H
and 20 more — show all
Sharp SA, Jie Y, Thompson WD, Harrison JW, Dawes A, Byrne EM, Tiemeier H, Allebrandt KV, Bowden J, Ray DW, Freathy RM, Murray A, Mazzotti DR, Gehrman PR, Lawlor DA, Frayling TM, Rutter MK, Hinds DA, Saxena R, Weedon MN
Nature communications · 2019 · PMID 30696823 · open access

From our blog

A wall clock turned back one hour beside a strand of DNA shaped like a clock hand

The Clocks Go Back. Your Body Clock Doesn’t: The Genes Behind Morning People and Night Owls

This month the clock on the wall moves by an hour, and the one inside you does not. The largest genetic study …

Questions about rs12030598

What is rs12030598?

rs12030598 is a single position in the genome, in or near the AK5 gene. Published research associates it with morning person. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs12030598 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12030598 come from?

GWAS Catalog, Nature communications 2019, PMID:30696823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Morning person (rs12030598). MyGeneLog™. https://www.mygenelog.com/variants/rs12030598

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