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Who was studied 13,685 European ancestry individuals; replicated in 15,854 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 2.98 msec higher (95% confidence interval 2.63-3.32); p = 3 × 10−45.
How common The A allele had a frequency of about 15% in the people studied.
Where it sits Chromosome 1, band 1q23.3 — in an intron of NOS1AP.
What each result means
A/ATwo copies of the version the research linked to QT interval. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to QT interval. That is a smaller link than two copies.
G/GNo copy of the version the research linked to QT interval. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs12029454
What is rs12029454?
rs12029454 is a single position in the genome, in or near the NOS1AP gene. Published research associates it with qt interval. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12029454 linked to?
On MyGeneLog this position is linked to QT Interval and Drug-Induced Long QT. The research behind each link, and its sources, are set out on that condition page.
Does rs12029454 affect how medicines work?
NOS1AP carries pharmacogenomic findings for QT-prolonging medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
What do people read about alongside rs12029454?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs12029454 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12029454 come from?
GWAS Catalog, Nat Genet 2009, PMID:19305408. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 491249222126Reads by AI crawlersClaude1ChatGPT2Google · Gemini0Perplexity4Meta AI9Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others26Total49Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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