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Prostate cancer

SLC39A1 · rs12027783

Where this position leads

Condition: Prostate Cancer

rs12027783 Condition: Prostate Cancer Prostate Cancer Condition rs12027783 rs12027783 SLC39A1

What the study found

Who was studied 5,764 African American or Afro-Caribbean cases, 42,247 African American or Afro-Caribbean controls, 28,645 European ancestry cases, 264,556 European ancestry controls, 1,678 Hispanic or Latin American cases, 24,750 Hispanic or Latin American controls.

The effect Each copy of the C allele shifted the measure 0.0718 lower (95% confidence interval 0.054-0.09); p = 3 × 10−13.

How common The C allele had a frequency of about 72% in the people studied.

Where it sits Chromosome 1, band 1q21.3 — in an intron of SLC39A1.

What each result means

C/C Two copies of the version the research linked to Prostate cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Prostate cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Prostate cancer. This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs12027783

What is rs12027783?

rs12027783 is a single position in the genome, in or near the SLC39A1 gene. Published research associates it with prostate cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs12027783 linked to?

On MyGeneLog this position is linked to Prostate Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs12027783 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12027783 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Prostate cancer (rs12027783). MyGeneLog™. https://www.mygenelog.com/variants/rs12027783

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