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Who was studied 806,834 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.0167 lower (95% confidence interval 0.012-0.021); p = 1 × 10−13.
How common The A allele had a frequency of about 17% in the people studied.
Where it sits Chromosome 1, band 1p35.1 — in an intron of NHSL3.
What each result means
A/ATwo copies of the version the research linked to Body mass index. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Body mass index. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Body mass index. This is the starting point the study compared everyone against.
Human molecular genetics · 2019 · PMID 30239722 · open access
Questions about rs12022461
What is rs12022461?
rs12022461 is a single position in the genome, in or near the NHSL3 gene. Published research associates it with body mass index. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12022461 linked to?
On MyGeneLog this position is linked to Childhood Body Mass Index, Obesity and Body Weight, Waist-to-Hip Ratio (Body Fat Distribution). The research behind each link, and its sources, are set out on that condition page.
Does having rs12022461 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12022461 come from?
GWAS Catalog, Human molecular genetics 2019, PMID:30239722. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 22123115Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others15Total22Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Body mass index (rs12022461). MyGeneLog™. https://www.mygenelog.com/variants/rs12022461