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Who was studied 12.945 European ancestry cases, 274,252 European ancestry controls; replicated in 4,242 European ancestry cases, 12,802 European ancestry controls.
The effect
Each copy of the C allele carried 1.09 times the odds of Basal cell carcinoma; p = 9 × 10−11.
How common The C allele had a frequency of about 74% in the people studied.
Where it sits Chromosome 8, band 8q21.13 — between genes, 6.7 kb from LOC105375921.
What each result means
C/CTwo copies of the version the research linked to Basal cell carcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Basal cell carcinoma. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Basal cell carcinoma. This is the starting point the study compared everyone against.
Nature communications · 2016 · PMID 27539887 · open access
Questions about rs11993814
What is rs11993814?
rs11993814 is a single position in the genome, in or near the ZBTB10 gene. Published research associates it with basal cell carcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11993814 linked to?
On MyGeneLog this position is linked to Basal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs11993814 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11993814 come from?
GWAS Catalog, Nat Commun 2016, PMID:27539887. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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