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Who was studied at least 5,877 East Asian ancestry cases, at least 188,588 East Asian ancestry controls, at least 14,355 European ancestry cases, at least 505,956 European ancestry controls, at least 1,393 admixed American ancestry cases, at least 2,327 admixed American ancestry controls (MTAG boosted by autoimmune diseases samples).
The effect
Each copy of the G allele shifted the measure 0.132 lower (95% confidence interval 0.092-0.172); p = 1 × 10−10.
Where it sits Chromosome 7, band 7q32.1 — between genes, 11 kb from TSPAN33.
What each result means
A/ANo copy of the version the research linked to Systemic lupus erythematosus (MTAG). This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Systemic lupus erythematosus (MTAG). That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Systemic lupus erythematosus (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2023 · PMID 36750564 · open access
Questions about rs11975493
What is rs11975493?
rs11975493 is a single position in the genome, in or near the near TSPAN33 gene. Published research associates it with systemic lupus erythematosus (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11975493 linked to?
On MyGeneLog this position is linked to Systemic Lupus Erythematosus. The research behind each link, and its sources, are set out on that condition page.
Does having rs11975493 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11975493 come from?
GWAS Catalog, Nature communications 2023, PMID:36750564. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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