Sensitive

Lung adenocarcinoma

POT1-AS1 · rs11975363

Where this position leads

Condition: EGFR Mutation-Positive Lung Adenocarcinoma

rs11975363 Condition: EGFR Mutation-Positive Lung Adenocarcinoma EGFR Mutation-Positive Lung Adenoca… Condition rs11975363 rs11975363 POT1-AS1

What the study found

Who was studied 13,292 European ancestry cases, 67,596 European ancestry controls; replicated in 7,042 European ancestry cases, 13,599 European ancestry controls.

The effect Each copy of the C allele carried 1.09 times the odds of Lung adenocarcinoma (95% confidence interval 1.06-1.116); p = 1 × 10−10.

How common The C allele had a frequency of about 48% in the people studied.

Where it sits Chromosome 7, band 7q31.33 — in an intron of POT1-AS1.

What each result means

C/C Two copies of the version the research linked to Lung adenocarcinoma. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Lung adenocarcinoma. That is a smaller link than two copies.
T/T No copy of the version the research linked to Lung adenocarcinoma. This is the starting point the study compared everyone against.
Source

Questions about rs11975363

What is rs11975363?

rs11975363 is a single position in the genome, in or near the POT1-AS1 gene. Published research associates it with lung adenocarcinoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11975363 linked to?

On MyGeneLog this position is linked to EGFR Mutation-Positive Lung Adenocarcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs11975363 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11975363 come from?

GWAS Catalog, Nature communications 2024, PMID:39366959. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung adenocarcinoma (rs11975363). MyGeneLog™. https://www.mygenelog.com/variants/rs11975363

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