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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
Strength of the evidence
1 / 4
Its strongest genetic-study result is p = 10−9, with 1 associations in the GWAS Catalog.
How this is scored
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 314,921 European ancestry individuals, 133,321 East Asian ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.0135 lower (95% confidence interval 0.009-0.018); p = 2 × 10−9.
Where it sits Chromosome 21, band 21q22.12 — inside RUNX1.
What each result means
C/CNo copy of the version the research linked to Serum total protein levels. This is the starting point the study compared everyone against.
C/GOne copy of the version the research linked to Serum total protein levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Serum total protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs119491 is a single position in the genome, in or near the RUNX1 gene. Published research associates it with serum total protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs119491 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs119491 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license
Serum total protein levels (rs119491). MyGeneLog™. https://www.mygenelog.com/variants/rs119491