Standard
Alcohol consumption
KLB · rs11940694
Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What each result means
A/A
Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Alcohol consumption compared to the general population.
A/G
Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Alcohol consumption.
G/G
Published research associates this genotype with typical/baseline likelihood of Alcohol consumption — no copies of the reported risk allele.
Source
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Schumann G,
Liu C,
O'Reilly P,
Gao H,
Song P,
Xu B,
Ruggeri B,
Amin N,
Jia T,
Preis S,
Segura Lepe M,
Akira S
and 115 more — show all
Barbieri C,
Baumeister S,
Cauchi S,
Clarke TK,
Enroth S,
Fischer K,
Hällfors J,
Harris SE,
Hieber S,
Hofer E,
Hottenga JJ,
Johansson Å,
Joshi PK,
Kaartinen N,
Laitinen J,
Lemaitre R,
Loukola A,
Luan J,
Lyytikäinen LP,
Mangino M,
Manichaikul A,
Mbarek H,
Milaneschi Y,
Moayyeri A,
Mukamal K,
Nelson C,
Nettleton J,
Partinen E,
Rawal R,
Robino A,
Rose L,
Sala C,
Satoh T,
Schmidt R,
Schraut K,
Scott R,
Smith AV,
Starr JM,
Teumer A,
Trompet S,
Uitterlinden AG,
Venturini C,
Vergnaud AC,
Verweij N,
Vitart V,
Vuckovic D,
Wedenoja J,
Yengo L,
Yu B,
Zhang W,
Zhao JH,
Boomsma DI,
Chambers J,
Chasman DI,
Daniela T,
de Geus E,
Deary I,
Eriksson JG,
Esko T,
Eulenburg V,
Franco OH,
Froguel P,
Gieger C,
Grabe HJ,
Gudnason V,
Gyllensten U,
Harris TB,
Hartikainen AL,
Heath AC,
Hocking L,
Hofman A,
Huth C,
Jarvelin MR,
Jukema JW,
Kaprio J,
Kooner JS,
Kutalik Z,
Lahti J,
Langenberg C,
Lehtimäki T,
Liu Y,
Madden PA,
Martin N,
Morrison A,
Penninx B,
Pirastu N,
Psaty B,
Raitakari O,
Ridker P,
Rose R,
Rotter JI,
Samani NJ,
Schmidt H,
Spector TD,
Stott D,
Strachan D,
Tzoulaki I,
van der Harst P,
van Duijn CM,
Marques-Vidal P,
Vollenweider P,
Wareham NJ,
Whitfield JB,
Wilson J,
Wolffenbuttel B,
Bakalkin G,
Evangelou E,
Liu Y,
Rice KM,
Desrivières S,
Kliewer SA,
Mangelsdorf DJ,
Müller CP,
Levy D,
Elliott P
Proceedings of the National Academy of Sciences of the United States of America · 2016 · PMID 27911795
Questions about rs11940694
What is rs11940694?
rs11940694 is a single position in the genome, in or near the KLB gene. Published research associates it with alcohol consumption. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does having rs11940694 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11940694 come from?
GWAS Catalog, Proc Natl Acad Sci U S A 2016, PMID:27911795. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
← See all variants