Sensitive

Lung cancer in never smokers

TP63 · rs11928222

Where this position leads

Condition: Lung Cancer

rs11928222 Condition: Lung Cancer Lung Cancer Condition rs11928222 rs11928222 TP63

What the study found

Who was studied 8,595 East Asian ancestry female cases, 8,275 East Asian ancestry female controls.

The effect Each copy of the G allele carried 1.21 times the odds of Lung cancer in never smokers (95% confidence interval 1.15-1.26); p = 3 × 10−16.

How common The G allele had a frequency of about 43% in the people studied.

Where it sits Chromosome 3, band 3q28 — in an intron of TP63.

What each result means

G/G Two copies of the version the research linked to Lung cancer in never smokers. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Lung cancer in never smokers. That is a smaller link than two copies.
T/T No copy of the version the research linked to Lung cancer in never smokers. This is the starting point the study compared everyone against.
Source

Questions about rs11928222

What is rs11928222?

rs11928222 is a single position in the genome, in or near the TP63 gene. Published research associates it with lung cancer in never smokers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11928222 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs11928222 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11928222 come from?

GWAS Catalog, International journal of cancer 2024, PMID:37846649. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Lung cancer in never smokers (rs11928222). MyGeneLog™. https://www.mygenelog.com/variants/rs11928222

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