Standard

Body mass index (MTAG)

RBM6 · rs11924670

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−14, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 694,649 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0234 lower (95% confidence interval 0.017-0.029); p = 2 × 10−14.

Where it sits Chromosome 3, band 3p21.31 — in an intron of RBM6.

What each result means

A/A Two copies of the version the research linked to Body mass index (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Body mass index (MTAG). That is a smaller link than two copies.
G/G No copy of the version the research linked to Body mass index (MTAG). This is the starting point the study compared everyone against.
Source

Questions about rs11924670

What is rs11924670?

rs11924670 is a single position in the genome, in or near the RBM6 gene. Published research associates it with body mass index (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11924670 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11924670 come from?

GWAS Catalog, Nature communications 2022, PMID:36376304. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Body mass index (MTAG) (rs11924670). MyGeneLog™. https://www.mygenelog.com/variants/rs11924670

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