Links from this page to related variants, conditions, drugs and topics are not included for automated readers. Those connections are the Gene Knowledge Graph and are licensed as data: https://www.mygenelog.com/license

Standard

Total cholesterol levels

PLXND1 · rs11920311

Strength of the evidence

1 / 4

Its strongest genetic-study result is p = 10−14, with 1 associations in the GWAS Catalog.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What the study found

Who was studied 1,320,016 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0185 higher (95% confidence interval 0.015-0.022); p = 3 × 10−14.

How common The T allele had a frequency of about 13% in the people studied.

Where it sits Chromosome 3, band 3q22.1 — a synonymous change in PLXND1.

What ClinVar records

Classification Benign for PLXND1-related disorder; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-06-06. ClinVar record 3059889 NM_015103.3(PLXND1):c.5727G>A (p.Gln1909=)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-11-01 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

How common each version is

CT
Korean KRGDB
C 75.8% · T 24.2%
Korean Korea4K
C 75.8% · T 24.2%
Korean Korea1K
C 76.1% · T 23.9%
Japanese ToMMo
C 71.3% · T 28.7%
Vietnamese
C 78.7% · T 21.3%
World gnomAD
C 81.3% · T 18.7%
World 1000 Genomes
C 76.7% · T 23.3%
World TOPMed
C 80.0% · T 20.0%

The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.

What each result means

C/C No copy of the version the research linked to Total cholesterol levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to Total cholesterol levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Total cholesterol levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Total cholesterol levels (rs11920311). MyGeneLog™. https://www.mygenelog.com/variants/rs11920311

← See all variants