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SARS-CoV-2 infection

near PDCL3P4 · rs11919389

What the study found

Who was studied 2,544 African ancestry cases, 31,176 African ancestry controls, 700 Middle Eastern ancestry cases, 13,360 Middle Eastern ancestry controls, 1,495 East Asian ancestry cases, 15,499 East Asian ancestry controls, 38,984 European ancestry cases, 1,644,784 European ancestry controls, 1,688 South Asian ancestry cases, 42,016 South Asian ancestry controls, 4,151 Hispanic or Latin American cases, 23,371 Hispanic or Latin American controls.

The effect Each copy of the C allele carried 0.94 times the odds of SARS-CoV-2 infection (95% confidence interval 0.9273018223094552-0.9556267949509863); p = 3 × 10−15.

How common The C allele had a frequency of about 35% in the people studied.

Where it sits Chromosome 3, band 3q12.3 — between genes, 6.9 kb from PDCL3P4.

What each result means

C/C Two copies of the version the research linked to SARS-CoV-2 infection. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to SARS-CoV-2 infection. That is a smaller link than two copies.
T/T No copy of the version the research linked to SARS-CoV-2 infection. This is the starting point the study compared everyone against.
Source

Questions about rs11919389

What is rs11919389?

rs11919389 is a single position in the genome, in or near the near PDCL3P4 gene. Published research associates it with sars-cov-2 infection. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11919389 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11919389 come from?

GWAS Catalog, Nature 2021, PMID:34237774. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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SARS-CoV-2 infection (rs11919389). MyGeneLog™. https://www.mygenelog.com/variants/rs11919389

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