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Prostaglandin-H2 D-isomerase protein levels (SomaScan ID:3376-49)

IL17RD · rs11916303

What the study found

Who was studied 200 Shetland Isles origin ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.77 lower (95% confidence interval 0.58-0.96); p = 4 × 10−18.

Where it sits Chromosome 3, band 3p14.3 — in a non-coding transcript of IL17RD.

What ClinVar records

Classification Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-08-09. ClinVar record 1237048 NM_017563.5(IL17RD):c.185-123G>T

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Prostaglandin-H2 D-isomerase protein levels (SomaScan ID:3376-49). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/C One copy of the version the research linked to Prostaglandin-H2 D-isomerase protein levels (SomaScan ID:3376-49). That is a smaller link than two copies.
C/C No copy of the version the research linked to Prostaglandin-H2 D-isomerase protein levels (SomaScan ID:3376-49). This is the starting point the study compared everyone against.
Source

Questions about rs11916303

What is rs11916303?

rs11916303 is a single position in the genome, in or near the IL17RD gene. Published research associates it with prostaglandin-h2 d-isomerase protein levels (somascan id:3376-49). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs11916303 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11916303 come from?

GWAS Catalog, Communications biology 2025, PMID:40883583. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Prostaglandin-H2 D-isomerase protein levels (SomaScan ID:3376-49) (rs11916303). MyGeneLog™. https://www.mygenelog.com/variants/rs11916303

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