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Who was studied 9,626 European ancestry cases, 685,602 European ancestry controls.
The effect
Each copy of the A allele carried 1.11 times the odds of Chronic rhinosinusitis with nasal polyposis (95% confidence interval 1.074-1.144); p = 1 × 10−10.
How common The A allele had a frequency of about 71% in the people studied.
Where it sits Chromosome 2, band 2p23.3 — in an intron of NCOA1.
What each result means
A/APublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Chronic rhinosinusitis with nasal polyposis compared to the general population.
A/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Chronic rhinosinusitis with nasal polyposis.
G/GPublished research associates this genotype with typical/baseline likelihood of Chronic rhinosinusitis with nasal polyposis — no copies of the reported risk allele.
Nature communications · 2025 · PMID 41213931 · open access
Questions about rs11894248
What is rs11894248?
rs11894248 is a single position in the genome, in or near the NCOA1 gene. Published research associates it with chronic rhinosinusitis with nasal polyposis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11894248 linked to?
On MyGeneLog this position is linked to Chronic Rhinosinusitis with Nasal Polyps. The research behind each link, and its sources, are set out on that condition page.
Does having rs11894248 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11894248 come from?
GWAS Catalog, Nature communications 2025, PMID:41213931. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 29111322316Reads by AI crawlersClaude1ChatGPT0Google · Gemini1Perplexity1Meta AI3Microsoft · Copilot2Amazon2Apple3Others16Total29Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Chronic rhinosinusitis with nasal polyposis (rs11894248). MyGeneLog™. https://www.mygenelog.com/variants/rs11894248