Sensitive

Crohn's disease

SOX11 · rs11894081

Where this position leads

Condition: Crohn's Disease

rs11894081 Condition: Crohn's Disease Crohn's Disease Condition rs11894081 rs11894081 SOX11

What the study found

Who was studied 372 Japanese ancestry cases,3,389 Japanese ancestry controls; replicated in Up to 1,151 Japanese ancestry cases, up to 15,800 Japanese ancestry controls.

The effect Each copy of the T allele carried 1.22 times the odds of Crohn's disease (95% confidence interval 1.2-1.22); p = 4 × 10−9.

How common The T allele had a frequency of about 55% in the people studied.

Where it sits Chromosome 2, band 2p25.2 — between genes, 16.2 kb from LOC107985842.

What each result means

G/G No copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11894081

What is rs11894081?

rs11894081 is a single position in the genome, in or near the SOX11 gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11894081 linked to?

On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.

Does having rs11894081 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11894081 come from?

GWAS Catalog, Gastroenterology 2012, PMID:23266558. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Crohn's disease (rs11894081). MyGeneLog™. https://www.mygenelog.com/variants/rs11894081

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