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Birth weight (full distribution)

near EPAS1 · rs11889459

Where this position leads

Condition: Birth Weight

rs11889459 Condition: Birth Weight Birth Weight Condition rs11889459 rs11889459 near EPAS1

What the study found

Who was studied 241,168 British ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0172 kg lower (95% confidence interval 0.014-0.021); p = 2 × 10−20.

What each result means

C/C Two copies of the version the research linked to Birth weight (full distribution). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Birth weight (full distribution). That is a smaller link than two copies.
T/T No copy of the version the research linked to Birth weight (full distribution). This is the starting point the study compared everyone against.
Source

Questions about rs11889459

What is rs11889459?

rs11889459 is a single position in the genome, in or near the near EPAS1 gene. Published research associates it with birth weight (full distribution). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11889459 linked to?

On MyGeneLog this position is linked to Birth Weight. The research behind each link, and its sources, are set out on that condition page.

Does having rs11889459 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11889459 come from?

GWAS Catalog, Diabetologia 2025, PMID:40210729. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Birth weight (full distribution) (rs11889459). MyGeneLog™. https://www.mygenelog.com/variants/rs11889459

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